StressCovidV1, Main, Exploration, bibRecord, 000875

Longitudinal multi-omics of host-microbe dynamics in prediabetes.

Identifieur interne : 000875 ( Main/Exploration ); précédent : 000874; suivant : 000876

Longitudinal multi-omics of host-microbe dynamics in prediabetes.

Auteurs : Wenyu Zhou [États-Unis] ; M Reza Sailani [États-Unis] ; Kévin Contrepois [États-Unis] ; Yanjiao Zhou [États-Unis] ; Sara Ahadi [États-Unis] ; Shana R. Leopold [États-Unis] ; Martin J. Zhang [États-Unis] ; Varsha Rao [États-Unis] ; Monika Avina [États-Unis] ; Tejaswini Mishra [États-Unis] ; Jethro Johnson [États-Unis] ; Brittany Lee-Mcmullen [États-Unis] ; Songjie Chen [États-Unis] ; Ahmed A. Metwally [États-Unis] ; Thi Dong Binh Tran [États-Unis] ; Hoan Nguyen [États-Unis] ; Xin Zhou [États-Unis] ; Brandon Albright [États-Unis] ; Bo-Young Hong [États-Unis] ; Lauren Petersen [États-Unis] ; Eddy Bautista [États-Unis] ; Blake Hanson [États-Unis] ; Lei Chen [États-Unis] ; Daniel Spakowicz [États-Unis] ; Amir Bahmani [États-Unis] ; Denis Salins [États-Unis] ; Benjamin Leopold [États-Unis] ; Melanie Ashland [États-Unis] ; Orit Dagan-Rosenfeld [États-Unis] ; Shannon Rego [États-Unis] ; Patricia Limcaoco [États-Unis] ; Elizabeth Colbert [États-Unis] ; Candice Allister [États-Unis] ; Dalia Perelman [États-Unis] ; Colleen Craig [États-Unis] ; Eric Wei [États-Unis] ; Hassan Chaib [États-Unis] ; Daniel Hornburg [États-Unis] ; Jessilyn Dunn [États-Unis] ; Liang Liang [États-Unis] ; Sophia Miryam Schüssler-Fiorenza Rose [États-Unis] ; Kim Kukurba [États-Unis] ; Brian Piening [États-Unis] ; Hannes Rost [Canada] ; David Tse [États-Unis] ; Tracey Mclaughlin [États-Unis] ; Erica Sodergren [États-Unis] ; George M. Weinstock [États-Unis] ; Michael Snyder [États-Unis]

Source :

Nature [ 1476-4687 ] ; 2019.

RBID : pubmed:31142858

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Antibactériens (administration et posologie), Biologie informatique, Diabète de type 2 (génétique), Diabète de type 2 (microbiologie), Diabète de type 2 (métabolisme), Données de la recherche comme sujet, Femelle, Glucose (métabolisme), Humains, Infections de l'appareil respiratoire (génétique), Infections de l'appareil respiratoire (microbiologie), Infections de l'appareil respiratoire (métabolisme), Infections de l'appareil respiratoire (virologie), Inflammation (métabolisme), Insuline (métabolisme), Insulinorésistance, Marqueurs biologiques (analyse), Marqueurs biologiques (métabolisme), Microbiome gastro-intestinal, Microbiote (physiologie), Mâle, Protéome (métabolisme), Stress physiologique, Sujet âgé, Transcriptome, Vaccination (), Vaccins antigrippaux (immunologie), Volontaires sains, État prédiabétique (génétique), État prédiabétique (microbiologie), État prédiabétique (métabolisme), Études de cohortes, Études longitudinales.
MESH :
- administration et posologie : Antibactériens.
- analyse : Marqueurs biologiques.
- génétique : Diabète de type 2, Infections de l'appareil respiratoire, État prédiabétique.
- immunologie : Vaccins antigrippaux.
- microbiologie : Diabète de type 2, Infections de l'appareil respiratoire, État prédiabétique.
- métabolisme : Diabète de type 2, Glucose, Infections de l'appareil respiratoire, Inflammation, Insuline, Marqueurs biologiques, Protéome, État prédiabétique.
- physiologie : Microbiote.
- virologie : Infections de l'appareil respiratoire.
- Adulte, Adulte d'âge moyen, Biologie informatique, Données de la recherche comme sujet, Femelle, Humains, Insulinorésistance, Microbiome gastro-intestinal, Mâle, Stress physiologique, Sujet âgé, Transcriptome, Vaccination, Volontaires sains, Études de cohortes, Études longitudinales.

English descriptors

KwdEn :
- Adult, Aged, Anti-Bacterial Agents (administration & dosage), Biomarkers (analysis), Biomarkers (metabolism), Cohort Studies, Computational Biology, Datasets as Topic, Diabetes Mellitus, Type 2 (genetics), Diabetes Mellitus, Type 2 (metabolism), Diabetes Mellitus, Type 2 (microbiology), Female, Gastrointestinal Microbiome, Glucose (metabolism), Healthy Volunteers, Host Microbial Interactions (genetics), Humans, Inflammation (metabolism), Influenza Vaccines (immunology), Insulin (metabolism), Insulin Resistance, Longitudinal Studies, Male, Microbiota (physiology), Middle Aged, Prediabetic State (genetics), Prediabetic State (metabolism), Prediabetic State (microbiology), Proteome (metabolism), Respiratory Tract Infections (genetics), Respiratory Tract Infections (metabolism), Respiratory Tract Infections (microbiology), Respiratory Tract Infections (virology), Stress, Physiological, Transcriptome, Vaccination (statistics & numerical data).
MESH :
- chemical , administration & dosage : Anti-Bacterial Agents.
- chemical , analysis : Biomarkers.
- chemical , immunology : Influenza Vaccines.
- chemical , metabolism : Biomarkers, Glucose, Insulin, Proteome.
- genetics : Diabetes Mellitus, Type 2, Host Microbial Interactions, Prediabetic State, Respiratory Tract Infections.
- metabolism : Diabetes Mellitus, Type 2, Inflammation, Prediabetic State, Respiratory Tract Infections.
- microbiology : Diabetes Mellitus, Type 2, Prediabetic State, Respiratory Tract Infections.
- physiology : Microbiota.
- statistics & numerical data : Vaccination.
- virology : Respiratory Tract Infections.
- Adult, Aged, Cohort Studies, Computational Biology, Datasets as Topic, Female, Gastrointestinal Microbiome, Healthy Volunteers, Humans, Insulin Resistance, Longitudinal Studies, Male, Middle Aged, Stress, Physiological, Transcriptome.

Abstract

Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early disease stages, its effects on biological processes or the transition to clinical T2D. To understand the earliest stages of T2D better, we obtained samples from 106 healthy individuals and individuals with prediabetes over approximately four years and performed deep profiling of transcriptomes, metabolomes, cytokines, and proteomes, as well as changes in the microbiome. This rich longitudinal data set revealed many insights: first, healthy profiles are distinct among individuals while displaying diverse patterns of intra- and/or inter-personal variability. Second, extensive host and microbial changes occur during respiratory viral infections and immunization, and immunization triggers potentially protective responses that are distinct from responses to respiratory viral infections. Moreover, during respiratory viral infections, insulin-resistant participants respond differently than insulin-sensitive participants. Third, global co-association analyses among the thousands of profiled molecules reveal specific host-microbe interactions that differ between insulin-resistant and insulin-sensitive individuals. Last, we identified early personal molecular signatures in one individual that preceded the onset of T2D, including the inflammation markers interleukin-1 receptor agonist (IL-1RA) and high-sensitivity C-reactive protein (CRP) paired with xenobiotic-induced immune signalling. Our study reveals insights into pathways and responses that differ between glucose-dysregulated and healthy individuals during health and disease and provides an open-access data resource to enable further research into healthy, prediabetic and T2D states.

DOI: 10.1038/s41586-019-1236-x
PubMed: 31142858

Affiliations:

Le document en format XML

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<author><name sortKey="Hong, Bo Young" sort="Hong, Bo Young" uniqKey="Hong B" first="Bo-Young" last="Hong">Bo-Young Hong</name>
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<author><name sortKey="Spakowicz, Daniel" sort="Spakowicz, Daniel" uniqKey="Spakowicz D" first="Daniel" last="Spakowicz">Daniel Spakowicz</name>
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<author><name sortKey="Bahmani, Amir" sort="Bahmani, Amir" uniqKey="Bahmani A" first="Amir" last="Bahmani">Amir Bahmani</name>
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<author><name sortKey="Salins, Denis" sort="Salins, Denis" uniqKey="Salins D" first="Denis" last="Salins">Denis Salins</name>
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<author><name sortKey="Leopold, Benjamin" sort="Leopold, Benjamin" uniqKey="Leopold B" first="Benjamin" last="Leopold">Benjamin Leopold</name>
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<author><name sortKey="Ashland, Melanie" sort="Ashland, Melanie" uniqKey="Ashland M" first="Melanie" last="Ashland">Melanie Ashland</name>
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<author><name sortKey="Dagan Rosenfeld, Orit" sort="Dagan Rosenfeld, Orit" uniqKey="Dagan Rosenfeld O" first="Orit" last="Dagan-Rosenfeld">Orit Dagan-Rosenfeld</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
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<author><name sortKey="Rego, Shannon" sort="Rego, Shannon" uniqKey="Rego S" first="Shannon" last="Rego">Shannon Rego</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
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<author><name sortKey="Limcaoco, Patricia" sort="Limcaoco, Patricia" uniqKey="Limcaoco P" first="Patricia" last="Limcaoco">Patricia Limcaoco</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
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</placeName>
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</author>
<author><name sortKey="Colbert, Elizabeth" sort="Colbert, Elizabeth" uniqKey="Colbert E" first="Elizabeth" last="Colbert">Elizabeth Colbert</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Endocrinology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
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<wicri:regionArea>Division of Endocrinology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
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<author><name sortKey="Allister, Candice" sort="Allister, Candice" uniqKey="Allister C" first="Candice" last="Allister">Candice Allister</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Endocrinology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
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<author><name sortKey="Perelman, Dalia" sort="Perelman, Dalia" uniqKey="Perelman D" first="Dalia" last="Perelman">Dalia Perelman</name>
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<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
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<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">États-Unis</country>
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<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
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<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Jackson Laboratory for Genomic Medicine, Farmington, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
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<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
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<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Jackson Laboratory for Genomic Medicine, Farmington, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Jackson Laboratory for Genomic Medicine, Farmington, CT</wicri:regionArea>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Jackson Laboratory for Genomic Medicine, Farmington, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
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<author><name sortKey="Hong, Bo Young" sort="Hong, Bo Young" uniqKey="Hong B" first="Bo-Young" last="Hong">Bo-Young Hong</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Jackson Laboratory for Genomic Medicine, Farmington, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
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<author><name sortKey="Petersen, Lauren" sort="Petersen, Lauren" uniqKey="Petersen L" first="Lauren" last="Petersen">Lauren Petersen</name>
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<placeName><region type="state">Connecticut</region>
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<author><name sortKey="Bautista, Eddy" sort="Bautista, Eddy" uniqKey="Bautista E" first="Eddy" last="Bautista">Eddy Bautista</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Jackson Laboratory for Genomic Medicine, Farmington, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
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</affiliation>
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<author><name sortKey="Hanson, Blake" sort="Hanson, Blake" uniqKey="Hanson B" first="Blake" last="Hanson">Blake Hanson</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Jackson Laboratory for Genomic Medicine, Farmington, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
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<author><name sortKey="Chen, Lei" sort="Chen, Lei" uniqKey="Chen L" first="Lei" last="Chen">Lei Chen</name>
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<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Connecticut</region>
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<author><name sortKey="Spakowicz, Daniel" sort="Spakowicz, Daniel" uniqKey="Spakowicz D" first="Daniel" last="Spakowicz">Daniel Spakowicz</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Salins, Denis" sort="Salins, Denis" uniqKey="Salins D" first="Denis" last="Salins">Denis Salins</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
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<author><name sortKey="Leopold, Benjamin" sort="Leopold, Benjamin" uniqKey="Leopold B" first="Benjamin" last="Leopold">Benjamin Leopold</name>
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<author><name sortKey="Rego, Shannon" sort="Rego, Shannon" uniqKey="Rego S" first="Shannon" last="Rego">Shannon Rego</name>
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</placeName>
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<author><name sortKey="Liang, Liang" sort="Liang, Liang" uniqKey="Liang L" first="Liang" last="Liang">Liang Liang</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Piening, Brian" sort="Piening, Brian" uniqKey="Piening B" first="Brian" last="Piening">Brian Piening</name>
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<author><name sortKey="Rost, Hannes" sort="Rost, Hannes" uniqKey="Rost H" first="Hannes" last="Rost">Hannes Rost</name>
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<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
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<author><name sortKey="Tse, David" sort="Tse, David" uniqKey="Tse D" first="David" last="Tse">David Tse</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Electrical Engineering, Stanford University, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Electrical Engineering, Stanford University, Stanford, CA</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Mclaughlin, Tracey" sort="Mclaughlin, Tracey" uniqKey="Mclaughlin T" first="Tracey" last="Mclaughlin">Tracey Mclaughlin</name>
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<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sodergren, Erica" sort="Sodergren, Erica" uniqKey="Sodergren E" first="Erica" last="Sodergren">Erica Sodergren</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Jackson Laboratory for Genomic Medicine, Farmington, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weinstock, George M" sort="Weinstock, George M" uniqKey="Weinstock G" first="George M" last="Weinstock">George M. Weinstock</name>
<affiliation wicri:level="2"><nlm:affiliation>The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. George.Weinstock@jax.org.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Jackson Laboratory for Genomic Medicine, Farmington, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
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<author><name sortKey="Snyder, Michael" sort="Snyder, Michael" uniqKey="Snyder M" first="Michael" last="Snyder">Michael Snyder</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. mpsnyder@stanford.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea>
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<series><title level="j">Nature</title>
<idno type="eISSN">1476-4687</idno>
<imprint><date when="2019" type="published">2019</date>
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<front><div type="abstract" xml:lang="en">Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early disease stages, its effects on biological processes or the transition to clinical T2D. To understand the earliest stages of T2D better, we obtained samples from 106 healthy individuals and individuals with prediabetes over approximately four years and performed deep profiling of transcriptomes, metabolomes, cytokines, and proteomes, as well as changes in the microbiome. This rich longitudinal data set revealed many insights: first, healthy profiles are distinct among individuals while displaying diverse patterns of intra- and/or inter-personal variability. Second, extensive host and microbial changes occur during respiratory viral infections and immunization, and immunization triggers potentially protective responses that are distinct from responses to respiratory viral infections. Moreover, during respiratory viral infections, insulin-resistant participants respond differently than insulin-sensitive participants. Third, global co-association analyses among the thousands of profiled molecules reveal specific host-microbe interactions that differ between insulin-resistant and insulin-sensitive individuals. Last, we identified early personal molecular signatures in one individual that preceded the onset of T2D, including the inflammation markers interleukin-1 receptor agonist (IL-1RA) and high-sensitivity C-reactive protein (CRP) paired with xenobiotic-induced immune signalling. Our study reveals insights into pathways and responses that differ between glucose-dysregulated and healthy individuals during health and disease and provides an open-access data resource to enable further research into healthy, prediabetic and T2D states.</div>
</front>
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<tree><country name="États-Unis"><region name="Californie"><name sortKey="Zhou, Wenyu" sort="Zhou, Wenyu" uniqKey="Zhou W" first="Wenyu" last="Zhou">Wenyu Zhou</name>
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<name sortKey="Perelman, Dalia" sort="Perelman, Dalia" uniqKey="Perelman D" first="Dalia" last="Perelman">Dalia Perelman</name>
<name sortKey="Petersen, Lauren" sort="Petersen, Lauren" uniqKey="Petersen L" first="Lauren" last="Petersen">Lauren Petersen</name>
<name sortKey="Piening, Brian" sort="Piening, Brian" uniqKey="Piening B" first="Brian" last="Piening">Brian Piening</name>
<name sortKey="Rao, Varsha" sort="Rao, Varsha" uniqKey="Rao V" first="Varsha" last="Rao">Varsha Rao</name>
<name sortKey="Rego, Shannon" sort="Rego, Shannon" uniqKey="Rego S" first="Shannon" last="Rego">Shannon Rego</name>
<name sortKey="Rose, Sophia Miryam Schussler Fiorenza" sort="Rose, Sophia Miryam Schussler Fiorenza" uniqKey="Rose S" first="Sophia Miryam Schüssler-Fiorenza" last="Rose">Sophia Miryam Schüssler-Fiorenza Rose</name>
<name sortKey="Sailani, M Reza" sort="Sailani, M Reza" uniqKey="Sailani M" first="M Reza" last="Sailani">M Reza Sailani</name>
<name sortKey="Salins, Denis" sort="Salins, Denis" uniqKey="Salins D" first="Denis" last="Salins">Denis Salins</name>
<name sortKey="Snyder, Michael" sort="Snyder, Michael" uniqKey="Snyder M" first="Michael" last="Snyder">Michael Snyder</name>
<name sortKey="Sodergren, Erica" sort="Sodergren, Erica" uniqKey="Sodergren E" first="Erica" last="Sodergren">Erica Sodergren</name>
<name sortKey="Spakowicz, Daniel" sort="Spakowicz, Daniel" uniqKey="Spakowicz D" first="Daniel" last="Spakowicz">Daniel Spakowicz</name>
<name sortKey="Tran, Thi Dong Binh" sort="Tran, Thi Dong Binh" uniqKey="Tran T" first="Thi Dong Binh" last="Tran">Thi Dong Binh Tran</name>
<name sortKey="Tse, David" sort="Tse, David" uniqKey="Tse D" first="David" last="Tse">David Tse</name>
<name sortKey="Wei, Eric" sort="Wei, Eric" uniqKey="Wei E" first="Eric" last="Wei">Eric Wei</name>
<name sortKey="Weinstock, George M" sort="Weinstock, George M" uniqKey="Weinstock G" first="George M" last="Weinstock">George M. Weinstock</name>
<name sortKey="Zhang, Martin J" sort="Zhang, Martin J" uniqKey="Zhang M" first="Martin J" last="Zhang">Martin J. Zhang</name>
<name sortKey="Zhou, Xin" sort="Zhou, Xin" uniqKey="Zhou X" first="Xin" last="Zhou">Xin Zhou</name>
<name sortKey="Zhou, Yanjiao" sort="Zhou, Yanjiao" uniqKey="Zhou Y" first="Yanjiao" last="Zhou">Yanjiao Zhou</name>
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<country name="Canada"><region name="Ontario"><name sortKey="Rost, Hannes" sort="Rost, Hannes" uniqKey="Rost H" first="Hannes" last="Rost">Hannes Rost</name>
</region>
</country>
</tree>
</affiliations>
</record>

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{{Explor lien
   |wiki=    Sante
   |area=    StressCovidV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:31142858
   |texte=   Longitudinal multi-omics of host-microbe dynamics in prediabetes.
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Serveur d'exploration Stress et Covid

Longitudinal multi-omics of host-microbe dynamics in prediabetes.

Longitudinal multi-omics of host-microbe dynamics in prediabetes.

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	Serveur d'exploration Stress et Covid
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